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KMID : 0363420210350040048
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Journal of Korean Oriental Pediatrics
2021 Volume.35 No. 4 p.48 ~ p.55
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Inflammation Relief Effect through ECS Control of Galgeunhwanggeumhwangryeon-tang Extract in Atopic Dermatitis
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Kim Ki-Bong
Ahn Sang-Hyun
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Abstract
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Objective: The purpose of this study was to confirm the effects of Galgeunhwanggeumhwangryeon-tang in reducing inflammation through the endocannabinoid system (ECS) control in atopic dermatitis.
Methods: 8-week-old Balb/C mice were divided into 4 groups: contorl group (Ctrl), lipid barrier elimination group (ADE), palmitoylethanolamide treated group after lipid barrier elimination (PEA), and Galgeunhwanggeumhwangryeon-tang applied group after lipid barrier elimination (GGRT). After inducing atopic dermatitis, cannabinoid receptor (CB) 1, CB2, CD68, phosphorylated inhibitor kappa B (p-IκB), inducible nitric oxide synthase (iNOS), substance P and serotonin were observed to confirm the regulation of the ECS, macrophage activity and mast cell activity.
Results: CB1 and CB2 showed higher positive reactions in the GGRT than in the LBE and PEA. CD68, p-IκB and iNOS showed higher positive reaction in the LBE, PEA and GGRT than in the Ctrl, but the increase in the positive reaction was lower in the GGRT compared to the LBE and PEA. Substance P and serotonin showed higher positive reaction in the LBE, PEA and GGRT than in the Ctrl, but the increase in the positive reaction was lower in the GGRT compared to the LBE and PEA.
Conclusions: The effects of Galgeunhwanggeumhwangryeon-tang were confirmed though the regulation of the ECS, macrophage activity and mast cell activity.
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KEYWORD
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Galgeunhwanggeumhwangryeon-tang, Atopic Dermatitis, Endocannabinoid system (ECS), cannabinoid receptor 1 (CB1), cannabinoid receptor 2 (CB2), Mast cell
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